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The Importance of Magnesium by Dr. Mar

by *Heather * on May 21, 2011

Magnesium has been referred to as the fifth but forgotten electrolyte.  Like calcium, only a small amount of body magnesium (Mg) is present in blood.  Approximately half the total Mg pools is present in soft tissue and the other half is present in the bone.  There are about 25 grams of magnesium in a person weighing 150 pounds, 53% is found in bone, 46% is in soft tissues and 1% is extracellular.
Magnesium is the second most abundant electrolyte next to potassium, and is a cofactor in more than 300 metabolic  reactions. In other words, magnesium is basically involved in all metabolic pathways.
  • Magnesium has a stabilizing effect on DNA and chromatin structure, and is an essential cofactor in almost all enzymatic systems involved in DNA processing.  
  • Magnesium is required for the removal of DNA damage generated by environmental mutagens, endogenous, process and DNA replication.
  • All components of connective tissue depend on magnesium. Four macro molecules make up connective tissue: collagen, elastin, proteoglycans, and glycoproteins. Magnesium serves to modulate the synthesis and degradation of both collagen and elastin. Proteoglycans, which allow for connective tissues to withstand compressive forces, and glycoproteins involved in connective tissue healing is regulated by magnesium.
  • The importance of magnesium in human health is taken much more seriously outside the United States. Israeli researchers explain that diverse clinical manifestations have been reported in conjunction with magnesium deficiencies, including sudden death, accelerated atherosclerosis, asthma, neurologic, and even psychiatric clinical entities. They summarize the current literature concerning magnesium supplementation and recommend supplementation on a national basis by adding magnesium to the water supplies of large areas.
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